NAG7 promotes human nasopharyngeal carcinoma invasion through inhibition of estrogen receptor alpha and up-regulation of JNK2/AP-1/MMP1 pathways
✍ Scribed by Chen Huang; Minghua Wu; Yunlian Tang; Xiaoling Li; Jue Ouyang; Lan Xiao; Dan Li; Guiyuan Li
- Book ID
- 102312781
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 492 KB
- Volume
- 221
- Category
- Article
- ISSN
- 0021-9541
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✦ Synopsis
Abstract
The NAG7, an estrogen receptor repressor, is a negative regulator of nasopharyngeal carcinoma cell growth. Here, we report that NAG7 promotes human nasopharyngeal carcinoma invasion, and we identify the mechanisms underlying this function. As a consequence of elevated NAG7 expression, the adhesion, migration, and invasive capabilities of HNE1 cells in vitro and in vivo were enhanced. NAG7 was a significant negative regulator of protein expression of estrogen receptor alpha (ERα), and activated both the JNK2/AP‐1/MMP1 and the upstream H‐Ras/p‐c‐Raf pathways. None of these effects induced by NAG7 over‐expression could be counteracted by estrogen. These observations indicate that NAG7 plays a potential role in promoting nasopharyngeal carcinoma invasion by regulation of ERα and the H‐ras/p‐c‐Raf and JNK2/AP‐1/MMP1 signaling pathways. J. Cell. Physiol. 221: 394–401, 2009. © 2009 Wiley‐Liss, Inc.