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NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation

✍ Scribed by Brennan, Angela M; Won Suh, Sang; Joon Won, Seok; Narasimhan, Purnima; Kauppinen, Tiina M; Lee, Hokyou; Edling, Ylva; Chan, Pak H; Swanson, Raymond A

Book ID
109938251
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
765 KB
Volume
12
Category
Article
ISSN
1097-6256

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## Abstract Hyperglycemia‐induced generation of reactive oxygen species (ROS) can lead to cardiomyocyte apoptosis and cardiac dysfunction. However, the mechanism by which high glucose causes cardiomyocyte apoptosis is not clear. In this study, we investigated the signaling pathways involved in NADP