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NADPH oxidase 1 plays a critical mediating role in oncogenic Ras-induced vascular endothelial growth factor expression

✍ Scribed by Komatsu, D; Kato, M; Nakayama, J; Miyagawa, S; Kamata, T

Book ID: 109970418
Publisher: Nature Publishing Group
Year: 2008
Tongue: English
Weight: 386 KB
Volume: 27
Category: Article
ISSN: 0950-9232
DOI: 10.1038/onc.2008.102

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## Abstract Her‐2/__neu__ (__erb__B‐2) oncogene overexpression is associated with increased tumor progression and metastasis. Fatty acid synthase (FAS), the key lipogenic enzyme responsible for the endogenous synthesis of fatty acids, has been shown to be one of the genes regulated by Her‐2/__neu__