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Na+ Channels with Binding Sites of High and Low Affinity for Tetrodotoxin in Different Excitable and Non-excitable Cells

✍ Scribed by Alain LOMBET; Christian FRELIN; Jean-François RENAUD; Michel LAZDUNSKI


Book ID
115121012
Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
535 KB
Volume
124
Category
Article
ISSN
1432-1327

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High and low affinity binding sites for
✍ David Moscatelli 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 834 KB

Scatchard analysis of binding of 125I-basic fibroblast growth factor (FGF) to baby hamster kidney (BHK) cells revealed the presence of two binding sites: a high affinity site with KD of 20 pM and 80,000 sites per cell and a low affinity site with KD of about 2 nM and 600,000 sites per cell. The bind