## Abstract For Abstract see ChemInform Abstract in Full Text.
β¦ LIBER β¦
N-triphenylphosphorylidene-1-(benzotriazol-1-yl)methylamine, a novel synthon equivalent to +CH2NH2: The preparation of primary amines
β Scribed by Alan R. Katritzky; Jinlong Jiang; Laszlo Urogdi
- Book ID
- 104229380
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 233 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
The preparation of primary amines has been accomplished by the connection of a HaN-CH, fragment to a functionalized carbon atom, both by using nucleophilic and by using electrophilic aminomethylation reactions.
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The utility of the diaminoquinazoline derivative CP-100,356 as an in vivo probe to selectively assess MDR1/BCRP-mediated drug efflux was examined in the rat. CP-100,356 was devoid of inhibition (IC 50 >50 mM) against major human P450 enzymes including P4503A4. In human MDR1-transfected MDCKII cells,