N-Terminal Cyclization of Peptides with N,N′-Carbonyldiimidazole or N,N′-Thiocarbonyldiimidazole
✍ Scribed by Dr. Franz Esser; Dr. Otto Roos
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- English
- Weight
- 197 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0044-8249
No coin nor oath required. For personal study only.
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The successful utilization of Schiff base peptide ester derivatives in sequence elucidation of peptides by mass spectrometry led to the study of N-terminal tryptophyl and histidyl peptides. We had earlier reported the formation of cyclization products when N-prolyl peptide esters had reacted with Sc
## Identification of N-terminal Tryptophan in Peptides Because of its complete destruction during the usual hydrolysis of peptides or of dansyl (5-dimethylamino-I-naphthalenesulfonyl) peptides with 6 N HCl, tryptophan or dansyl-tryptophan (DNS-tryptophan) may not be identified after this treatment