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N-Substitution of 2-methyl-4(5)-nitro-1H-imidazole: a new, high-yield method for preparation of 4-nitro isomers

✍ Scribed by Rao, A. K. S. Bhujanga; Rao, C. Gundu; Singh, B. B.


Book ID
115314183
Publisher
American Chemical Society
Year
1990
Tongue
English
Weight
400 KB
Volume
55
Category
Article
ISSN
0022-3263

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## Abstract magnified image Oxidation of metronidazole (**4**) with sodium dichromate yielded the corresponding 2‐(2‐methyl‐5‐nitro‐1__H__‐imidazol‐1‐yl)acetic acid (**5**) which was esterified with 1‐butanol to give butyl 2‐(2‐methyl‐5‐nitro‐1__H__‐imidazol‐1‐yl)acetate (**8**). Reaction of the l