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N-(substituted-phenyl) piperazines: antagonists with high binding and functional selectivity for dopamine D4 receptors

โœ Scribed by Izzy Boyfield; Martyn C. Coldwell; Michael S. Hadley; Maureen A.M. Healy; Amanda Johns; David J. Nash; Graham J. Riley; Emma E. Scott; Stephen A. Smith; Geoffrey Stemp; Karl Wilson


Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
241 KB
Volume
6
Category
Article
ISSN
0960-894X

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2-[(substituted)phenyl]-5-[1-(2-phenylaz
โœ David Bolton; Izzy Boyfield; Martyn C. Coldwell; Michael S. Hadley; Amanda Johns ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 192 KB

A series of 2-1(substituted)phenyl]-5-[1-(2-phenylazacycloheptyl)methyl]-lH-pyrroles (8 -15) has been prepared to investigate the effect on affinity and selectivity for the dopamine D 3 receptor of modifying the substituent in the phenyl ring at the 2-position of the pyrrole. Sulfonate 7 and sulfona