N-substituted isoquinoline derivatives as potential AChE inhibitors

✍ Scribed by Rosaria Gitto; Laura De Luca; Stefania Ferro; Sara De Grazia; Rosa Maria Di Giorgio; Filomena Festa; Grazia De Luca

• Book ID: 102342080
• Publisher: Journal of Heterocyclic Chemistry
• Year: 2009
• Tongue: English
• Weight: 135 KB
• Volume: 47
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.252

✦ Synopsis

Abstract

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N‐substituted donepezil‐related isoquinolines have been prepared as potential acetylcholinesterase inhibitors (AChEIs). Microwave assisted procedures and solution‐phase parallel synthesis were chosen to optimize the synthetic approach and improve the yields. All synthesized compounds were tested for their AChE inhibitory activity by colorimetric Ellman method and some of them (10, 13, and 28) displayed low inhibitory effects at μ__M__ concentrations. J. Heterocyclic Chem., (2010).