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N-Substituted cis- 4a-(3-Hydroxyphenyl)-8a-methyloctahydroisoquinolines Are Opioid Receptor Pure Antagonists

✍ Scribed by Carroll, F. Ivy; Chaudhari, Sachin; Thomas, James B.; Mascarella, S. Wayne; Gigstad, Kenneth M.; Deschamps, Jeffrey; Navarro, Hernán A.


Book ID
125972855
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
276 KB
Volume
48
Category
Article
ISSN
0022-2623

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Synthesis of N- Substituted 4-(4-Hydroxy
✍ Guzikowski, Anthony P.; Tamiz, Amir P.; Acosta-Burruel, Manuel; Hong-Bae, Soo; C 📂 Article 📅 2000 🏛 American Chemical Society 🌐 English ⚖ 337 KB

Antagonists at the 1A/2B subtype of the NMDA receptor (NR1A/2B) are typically small molecules that consist of a 4-benzyl-or a 4-phenylpiperidine with an ω-phenylalkyl substituent on the heterocyclic nitrogen. Many of these antagonists, for example ifenprodil (1), incorporate a 4-hydroxy substituent