N-oxidation and degradation of pyrrolizidine alkaloids during germination of Crotalaria scassellatii
β Scribed by Gerd Toppel; Ludger Witte; Thomas Hartmann
- Book ID
- 103340141
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 317 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0031-9422
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π SIMILAR VOLUMES
Cell-suspension cultures of pyrrolizidinealkaloid-producing species selectively take up and accumulate senecionine (sen) and its N-oxide (sen-Nox). Cultures established from non-alkaloid-producing species are unable to accumulate the alkaloids. The uptake and accumulation of 14C-labelled alkaloids w
Sceleratine [l] and its N-oxide [Z] have been isolated from Senecio ZatifoZius DC and their structures determined by spectroscopic and chemical methods and X-ray crystal= lography. Recently we isolated the N-oxide of merenskine [3],' a new pyrrolizidine alkaloid N-oxide from Senecio Zatifolius DC.'
14C-Labelled alkaloid precursors (arginine, putrescine, spermidine) fed to Senecio vulgaris plants via the root system were rapidly taken up and efficiently incorporated into the pyrrolizidine alkaloid senecionine N-oxide (sen-Nox) with total incorporations of 3-6%. Considerable amounts of labelled