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N-Nitroso-2-acetylaminofluorene: A Direct-acting Carcinogen Inducing Hepatocellular Carcinoma in Sprague-Dawley Rats

✍ Scribed by Ho, Yuan-Soon ;Lin, Jen-Kun

Book ID
108580945
Publisher
Wiley (Blackwell Publishing)
Year
1994
Tongue
English
Weight
896 KB
Volume
85
Category
Article
ISSN
0910-5050

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p53 gene mutational spectra in hepatocel
p53 gene mutational spectra in hepatocellular carcinomas induced by 2-acetylaminofluorene and N-nitroso-2-acetylaminofluorene in rats
✍ Yuan-Soon Ho; Hui-Teng Cheng; Ying-Jan Wang; Jen-Kun Lin 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 674 KB

## Abstract In this study, the mutation frequencies of the p53 gene in rat hepatocellular carcinomas (HCCs) induced by __N__‐nitroso‐2‐acetylaminofluorene (NO‐AAF) and 2‐acetylaminofluorene (AAF) were 19.23% (20 of 104) and 31.1% (33 of 106), respectively. Four noteworthy features of the mutation s