N-Myc and Bcl-2 coexpression induces MMP-2 secretion and activation in human neuroblastoma cells
β Scribed by van Golen, Cynthia M; van Golen, Kenneth L; Grauman, Alyssa; Feldman, Eva L; Noujaim, Daniel
- Book ID
- 110066736
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 317 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0950-9232
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The potent antiapoptotic molecule Bclβ2 is markedly upβregulated in a majority of cancers, including neuroblastoma. Genistein is an isoflavone with antitumor properties. The present study sought to elucidate the molecular mechanism of genisteinβinduced apoptosis and also to examine the
bcl-2 expression is often associated with poor prognosis in several types of tumors; however, the role of this molecule in breast cancer is still controversial. We found earlier that over-expression of bcl-2 in a human breast-cancer cell line (MCF7 ADR ) enhances its tumorigenicity and metastatic po