N-Monoalkylation of α-Amino Acid Esters under Solid-Liquid PTC Conditions

✍ Scribed by Domenico Albanese; Dario Landini; Vittoria Lupi; Michele Penso

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 334 KB
• Volume: 2000
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/(sici)1099-0690(200004)2000:8<1443::aid-ejoc1443>3.0.co;2-5

✦ Synopsis

N-(2-Nitrophenylsulfonyl)-(o-NBS-AA-OMe, 4) and N-(4-Nitrophenylsulfonyl)-α-amino acid methyl esters (p-NBS-AA-OMe, 5) were N-alkylated with a variety of alkyl halides 6 under solid-liquid phase-transfer catalysis (SL-PTC) condi-Scheme 1. Preparation of N-alkylated α