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N-methyl poly(α-amino acids). Synthesis and preliminary conformational analysis of poly(N-methyl-γ-methyl-L-glumate)

✍ Scribed by Alessandro Cosani; Manlio Palumbo; Maria Terbojevich; Evaristo Peggion

Publisher
Wiley (John Wiley & Sons)
Year
1978
Tongue
English
Weight
121 KB
Volume
17
Category
Article
ISSN
0006-3525

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✦ Synopsis

N-Methyl Poly(a -Amino Acids). Synthesis and Preliminary Conformational Analysis of Poly(N-Methyl-y -Methyl-L-Glutamate)

N-substituted polypeptides exhibit very interesting conformational properties, due to the lack of hydrogen bonding from the N-H group in the main chain, and to the possibility of cis and trans configurations of the peptide bond.

The synthesis of N-methyl poly(u-amino acids) starting from the N-substituted N-carboxy anhydrides (NCAs) has been reported only for polysarcosine and poly(N-methyl-L-alanine), yielding low-molecular-weight materials.14 All other N-substituted NCAs do not polymerize

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