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N-Methyl-phenacyloxycarbamidomethyl (Pocam) group: a novel thiol protecting group for solid-phase peptide synthesis and peptide condensation reactions

✍ Scribed by Katayama, Hidekazu; Nakahara, Yoshiaki; Hojo, Hironobu

Book ID
118206928
Publisher
Royal Society of Chemistry
Year
2011
Tongue
English
Weight
627 KB
Volume
9
Category
Article
ISSN
1477-0520

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## Abstract A new water‐soluble __N__‐protecting group, 2‐[phenyl(methyl)sulfonio]ethyloxycarbonyl tetrafluoroborate, has been prepared and its application to solid phase peptide synthesis in water has been studied. Leu‐enkephalin amide was successfully synthesized in water by the solid phase metho