N-methyl-N′-nitro-N-nitrosoguanidine-induced resistance to ionizing radiation

✍ Scribed by Morse, M. L. ;Smith, Diana S.

• Book ID: 104726916
• Publisher: Springer
• Year: 1987
• Tongue: English
• Weight: 566 KB
• Volume: 206
• Category: Article
• ISSN: 0026-8925
• DOI: 10.1007/bf00333577

✦ Synopsis

N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) pretreatments increase the resistance of Escherichia coli to gamma-radiation. The increased resistance is dependent on functional polA, recA, recB, recC, and lexA genes and is partly dependent on recN. The MNNG-induced resistance is additive to resistance induced by pretreatment with gamma-radiation but not by increases induced by hydrogen peroxide. The MNNG-induced resistance occurs in adaptive response mutants and at pretreatment levels of MNNG that do not activate cells to reactivate UV-inactivated lambda phage. The MNNG-induced resistance appears to be distinct from other inductions to gamma-radiation resistance.