N-Methyl-d-aspartate receptor antagonist MK-801 induced circling behavior in rats with unilateral striatal ischemic lesions or nigral 6-hydroxydopamine lesions
✍ Scribed by Satoshi Goto; Kojiro Korematsu; Nobuhiro Inoue; Kazumichi Yamada; Taro Oyama; Shinji Nagahiro; Yukitaka Ushio
- Publisher
- Springer-Verlag
- Year
- 1993
- Tongue
- English
- Weight
- 601 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0001-6322
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✦ Synopsis
The present study shows that systemic administration of the selective, non-competitive N-methyl-D-aspartate antagonist MK-801 [(+)-5-methyl-10,11-dihydroxy-5H-dibenzo (a,d)-cyclohepten-5,10-imine] dose-dependently induces ipsiversive rotational behavior in the rats with a unilateral striatal lesion produced by transient middle cerebral artery occlusion or in those with a unilateral nigrostriatal lesion produced by 6-hydroxydopamaine. In relation to a functional model of the basal ganglia-thalamocortical 'motor' circuit, the present data suggest that the striatum may be one of the most important sites where MK-801 acts in the basal ganglia, with its being responsible for the circling behavior of the animal models.