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N-linked glycosylation of dipeptidyl peptidase IV (CD26): Effects on enzyme activity, homodimer formation, and adenosine deaminase binding

✍ Scribed by Kathleen Aertgeerts; Sheng Ye; Lihong Shi; Sridhar G. Prasad; Darbi Witmer; Ellen Chi; Bi-Ching Sang; Robert A. Wijnands; David R. Webb; Ronald V. Swanson


Book ID
119824271
Publisher
Cold Spring Harbor Laboratory Press
Year
2004
Tongue
English
Weight
330 KB
Volume
13
Category
Article
ISSN
0961-8368

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While adenosine deaminase (ADA) is an established malignancy marker and its clinical involvement in severe combined immunodeficiency (SCID) is understood, the biological significance of its binding to adenosine deaminase complexing protein (CP = DPPIV = CD26) remains enigmatic. The role of lipid-pro