## Abstract The reaction of (E)โ3โarylโ2โpropenoic acid derivatives with (Nโisocyanimino) triphenylphosphorane proceeds smoothly at room temperature to afford the corresponding 2โ[(E)โ2โarylโ1โethenyl]โ1,3,4โoxadiazole via an intramolecular azaโWittig reaction in good yields under neutral condition
( N -Isocyanimino)triphenylphosphorane-Mediated, One-Pot, Efficient Synthesis of Sterically Congested 1,1,1-Trifluoro-2-(5-aryl-1,3,4-oxadiazol-2-yl)-2-propanol Derivatives via Intramolecular Aza-Wittig Reaction
โ Scribed by Ramazani, Ali; Shajari, Nahid; Mahyari, Amir Tofangchi; Khoobi, Mehdi; Ahmadi, Yavar; Souldozi, Ali
- Book ID
- 125549315
- Publisher
- Taylor and Francis Group
- Year
- 2010
- Tongue
- English
- Weight
- 144 KB
- Volume
- 185
- Category
- Article
- ISSN
- 1042-6507
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๐ SIMILAR VOLUMES
Reactions of biacetyl (ยผ butane-2,3-dione) with (N-isocyanimino)triphenylphosphorane in the presence of aromatic carboxylic acids proceed smoothly at room temperature and under neutral conditions to afford 3-(5-aryl-1,3,4-oxadiazol-2-yl)-3-hydroxybutan-2-one derivatives in high yields. Introduction
## Abstract Reactions of (__N__โisocyanimino) triphenylphosphorane with 2โoxopropylbenzoate (or acetate) in the presence of aromatic carboxylic acids and primary amines proceed smoothly at room temperature and in neutral conditions to afford sterically congested 1,3,4โoxadiazole derivatives in high