𝔖 Bobbio Scriptorium
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N-hydroxylation of p-chloroacetanilide in hamsters

✍ Scribed by Jack A. Hinson; Jerry R. Mitchell; David J. Jollow


Book ID
115773195
Publisher
Elsevier Science
Year
1976
Tongue
English
Weight
289 KB
Volume
25
Category
Article
ISSN
0006-2952

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Solvolysis–decomposition of N-1-adamanty
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In hydroxylic solvents, N-1-adamantyl-N-p-tolylcarbamoyl chloride undergoes a facile rate-determing ionization with very little assistance from nucleophilic solvation (very low sensitivity to changes in solvent nucleophilicity). In the relatively nucleophilic aqueous ethanol or aqueous acetone, the