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n-Hexane-induced parkinsonism: Pathogenetic hypotheses

✍ Scribed by Dr. G. Pezzoli; A. Antonini; S. Barbieri; M. Canesi; L. Perbellini; A. Zecchinelli; C. B. Mariani; A. Bonetti; K. L. Leenders

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
353 KB
Volume
10
Category
Article
ISSN
0885-3185

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✦ Synopsis

n-Hexane, similar hydrocarbons, and derivatives are common environmental pollutants and by-products of lipid peroxidation, and they may have a nigrotoxic effect like that of l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine. This report describes our second case of parkinsonism in a subject exposed to n-hexane. Positron emission tomography studies demonstrated regional striatal abnormalities of the nigrostriatal dopaminergic system and of glucose metabolism that were different from those found in idiopathic Parkinson's disease.

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