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N-Glycosylation modulates the cell-surface expression and catalytic activity of corin

✍ Scribed by Inna P. Gladysheva; Sarah M. King; Aiilyan K. Houng


Book ID
116296989
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
549 KB
Volume
373
Category
Article
ISSN
0006-291X

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## Abstract Mutations in the gene encoding ClC‐5 lead to X‐linked hypercalciuric nephrolithiasis (XLHN), characterized by proteinuria, hypercalciuria, and phosphaturia. In renal proximal tubule cells, ClC‐5 was identified as an important player in endocytosis, which ensures reabsorption of filtered