N-glycan of ErbB family plays a crucial role in dimer formation and tumor promotion

Crucial role of synovial lining macropha

Crucial role of synovial lining macrophages in the promotion of transforming growth factor β–mediated osteophyte formation

✍ P. L. E. M. Van Lent; A. B. Blom; P. Van Der Kraan; A. E. M. Holthuysen; E. Vitt 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 300 KB

## Abstract ## Objective To investigate in vivo and in vitro whether macrophages have an intermediate role in transforming growth factor β (TGFβ)–induced osteophyte formation. ## Methods In vivo, synovial lining macrophages were selectively depleted by injection of clodronate‐laden liposomes 7 d