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N + -Glucuronidation of aliphatic tertiary amines, a general phenomenon in the metabolism of H 1 -antihistamines in humans

โœ Scribed by Luo, H.; Hawes, E. M.; McKay, G.; Korchinski, E. D.; Midha, K. K.


Book ID
126722628
Publisher
Informa plc
Year
1991
Tongue
English
Weight
582 KB
Volume
21
Category
Article
ISSN
0049-8254

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1H-CIDNP effects in the reaction of N-hy
โœ Ido P. Bleeker; Jan B. F. N. Engberts ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 475 KB

## Abstract __tert__โ€Butylsulfinyl chloride (**1**) reacts smoothly with __N__โ€ฒโ€(di)methylโ€ and __N__โ€ฒโ€(di)phenylโ€__N__โ€hydroxyurea (**2**) in acetone at room temperature, in the presence of two equivalents of pyridine. An intermediate __Oโ€tert__โ€butylsulfinylโ€__N__โ€hydroxyurea (**3**) is postulate