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N G -Acylated Imidazolylpropylguanidines as Potent Histamine H 4 Receptor Agonists: Selectivity by Variation of the N G -Substituent ▽

✍ Scribed by Igel, Patrick; Schneider, Erich; Schnell, David; Elz, Sigurd; Seifert, Roland; Buschauer, Armin


Book ID
118010802
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
111 KB
Volume
52
Category
Article
ISSN
0022-2623

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Inside Cover: Tritium-Labeled N1-[3-(1H-
✍ Patrick Igel; David Schnell; Günther Bernhardt; Roland Seifert; Armin Buschauer; 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 393 KB 👁 1 views

## Abstract The inside cover picture shows the human histamine H~2~ receptor and the H~2~ and H~3~/H~4~ receptor‐selective ligands identified. Bioisosteric replacement of the imidazole ring of the __N__^G^‐acyl‐imidazolylpropylguanidine with 2‐aminothiazole yielded potent and selective H~2~ recepto