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N-ethylmaleimide irreversibly inhibits the binding of [3H]threo-(±)-methylphenidate to the stimulant recognition site

✍ Scribed by M.M. Schweri


Book ID
118956329
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
1003 KB
Volume
29
Category
Article
ISSN
0028-3908

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Mercuric chloride was found to have a biphasic effect on the binding of the radiolabeled stimulant [3H]methylphenidate to membranes from a crude synaptoso-ma1 preparation of rat striatal tissue. Binding was enhanced at low concentrations of HgCl,, reaching a maximum of 62% above control values at 2.