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N-Chlorosuccinimide is a convenient oxidant for the synthesis of 2,4-disubstituted 1,2,4-thiadiazolidine-3,5-diones

✍ Scribed by Shama Nasim; Peter A. Crooks

Book ID
104095991
Publisher
Elsevier Science
Year
2009
Tongue
French
Weight
163 KB
Volume
50
Category
Article
ISSN
0040-4039

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✦ Synopsis

N-Chlorosuccinimide has been identified as a convenient and safe alternative oxidant for the oxidative condensation of isothiocyanates and isocyanates to afford 1,2,4-thiadiazolidine-3,5-diones.

πŸ“œ SIMILAR VOLUMES

An improved procedure for the synthesis
An improved procedure for the synthesis of 4,4-disubstituted-3-oxo-1,2,5-thiadiazolidine 1,1 -dioxides
✍ Zejun Xiao; Jack W. Timberlake πŸ“‚ Article πŸ“… 2000 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 326 KB

## Abstract An improved synthesis for the preparation of 3‐oxo‐1,2,5‐thiadiazolidine 1,1‐dioxides has been developed. This facile two‐step procedure fromα‐amino acid esters and chlorosulfonyl isocyanate results in excellent yields of products.