E-cadherin is the major cell-cell adhesion molecule expressed by epithelial cells. Cadherins form a complex with three cytoplasmic proteins, โฃ-, โค-, and โฅ-catenin, and the interaction between them is crucial for anchoring the actin cytoskeleton to the intercellular adherens junctions. The invasive b
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N-cadherin-mediated adhesion and aberrant catenin expression in anaplastic thyroid-carcinoma cell lines
โ Scribed by Johanna Husmark; Nils-Erik Heldin; Mikael Nilsson
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- French
- Weight
- 529 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0020-7136
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The cadherin/catenin complex plays a key role in the initiation of cell-cell recognition, and adhesion, and the elaboration of structural and functional organization in multicellular tissues and organs. It is associated with tumor metastasis and also acts as an ''invasion suppressor'' of cancer cell