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N-Benzylpiperazino derivatives of 3-nitro-4-hydroxycoumarin with H1 antihistamine and mast cell stabilizing properties

✍ Scribed by Buckle, Derek R.; Outred, D. James; Smith, Harry; Spicer, Barbara A.


Book ID
115437648
Publisher
American Chemical Society
Year
1984
Tongue
English
Weight
808 KB
Volume
27
Category
Article
ISSN
0022-2623

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The redction of N,N -dimethyl-2-nitroethene-I,l-diamine (8) with cc,j-unsaturdted dcyl ISOthiOCydndteS 9 dffords 3,3-diamino-2-nitroacrylthioamides 10 (Scheme 2) in moderate-to-good yields Cyclization of 10 under acidic conditions gives 1,3-thiazin-4-one derivatives of type 11 Oxiddtive cyclization