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N-Arylation of N-H heterocycles with aryl bromides and aryl iodides using cui and kf/Al2O3

✍ Scribed by Rahman Hosseinzadeh; Mahmood Tajbakhsh; Mohammad Alikarami; Maryam Mohadjerani

Publisher
Journal of Heterocyclic Chemistry
Year
2008
Tongue
English
Weight
283 KB
Volume
45
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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Copper‐catalyzed system for N‐arylation of N‐H group in heterocycles such as indole, pyrrole and carbazole with aryl iodides and aryl bromides using potassium fluoride supported on alumina as a base is described. This is a simple and efficient method for the coupling of aryl iodides and bromides with N‐H heterocycles. Different functionalized iodo and bromo arenes were coupled with N‐H heterocycles using this system.

πŸ“œ SIMILAR VOLUMES

CuI-catalyzed Coupling Reactions of Aryl
CuI-catalyzed Coupling Reactions of Aryl Iodides with Amides Using L-Proline and KF/Al2O3
✍ Rahman HOSSEINZADEH; Mahmood TAJBAKHSH; Maryam MOHADJERANI; Elham GHORBANI πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 82 KB πŸ‘ 2 views

An efficient experimentally simple and inexpensive catalyst system for the selective amidation of aryl iodides using 15 mol% of CuI as catalyst, 15 mol% of L-proline as ligand and KF/Al 2 O 3 as a base in toluene is described.