N-Alkylation of Amides. A Novel Procedure
โ Scribed by Johnson, Herbert E.; Crosby, Donald G.
- Book ID
- 127109960
- Publisher
- American Chemical Society
- Year
- 1962
- Tongue
- English
- Weight
- 132 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0022-3263
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Relatively few reliable methods are currently available for the mono-N-alkylation of amides, lactams, ureas, carbamates and other similar types of functionality. 2-4 recently reported4 two methods for N-methylation of such compounds y\_& reduction of We
A one pot selective mend N-alkylation of primary amides, thioamides, carbamates and ureas has been developed using aromatic and aliphatic aldehydes as alkylating agents and trifluoroacetic acid / triethylsilane as reagents. Application to an efficient synthesis of a primary amine from the correspond