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N-acyl-N-formylcarbamates. A new class of carbamate derivatives

✍ Scribed by M. L. Graziano; M. R. Iesce; R. Scarpalixs


Book ID
112125541
Publisher
Journal of Heterocyclic Chemistry
Year
1979
Tongue
English
Weight
217 KB
Volume
16
Category
Article
ISSN
0022-152X

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(N-acyl-N-alkyl)glycyl borolysine analog
✍ Robert A. Galemmo Jr.; John M. Fevig; David J. Carini; Joseph Cacciola; Brian L. πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 372 KB

In this report the structure-activity relationships of a series of novel (N-acyl-N-alkyl)glycyl borolysine thrombin inhibitors are described. This work culminates in the discovery of (N-3phenylpropanoyl-N-phenethyl)glycyl borolysine (12j), a potent, orally active inhibitor with a binding conformatio