N-acetyl-N-oxo-1,4-benzoquinone imine, observation of an acyl nitrone

✍ Scribed by Paul F. Alewood; Ian C. Calder; Roger Fernando; Kevin Healey; Robyn Richardson

• Book ID: 104226791
• Publisher: Elsevier Science
• Year: 1985
• Tongue: French
• Weight: 173 KB
• Volume: 26
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)94855-x

✦ Synopsis

N-Acetyl-N-oxo-1,4_benzoquinone imine, an N-acyl nitrone has been prepared and its intramolecular rearrangement to N-acetoxy-1,4-benzoquinone imine observed using IH-NMR spectroscopy. The analgesic paracetamol (1) is linked with liver necrosis in man and experimental animals when taken in high doses'.