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N-acetyl cysteine enhances imatinib-induced apoptosis of Bcr-Abl+cells by endothelial nitric oxide synthase-mediated production of nitric oxide

✍ Scribed by Srabanti Rakshit; Jayashree Bagchi; Labanya Mandal; Kausik Paul; Dipyaman Ganguly; Sandip Bhattacharjee; Monidipa Ghosh; Nabendu Biswas; Utpal Chaudhuri; Santu Bandyopadhyay


Publisher
Springer
Year
2009
Tongue
English
Weight
626 KB
Volume
14
Category
Article
ISSN
1360-8185

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It has been demonstrated that nitric oxide (NO) can promote apoptosis in human cancer cells. To test the protective effects of antioxidants (N-acetyl-L-cysteine (LNAC)) and free-radical spin traps (5,5-dimethyl-1-pyrroline N-oxide and 2,2,6,6,-tetramethyl-1-piperidinyloxy) against NO-induced apoptos