✦ LIBER ✦

N 6 -Substituted D-4‘-Thioadenosine-5‘-methyluronamides: Potent and Selective Agonists at the Human A 3 Adenosine Receptor

✍ Scribed by Jeong, Lak Shin; Jin, Dong Zhe; Kim, Hea Ok; Shin, Dae Hong; Moon, Hyung Ryong; Gunaga, Prashantha; Chun, Moon Woo; Kim, Yong-Chul; Melman, Neli; Gao, Zhan-Guo; Jacobson, Kenneth A.

Book ID: 120444976
Publisher: American Chemical Society
Year: 2003
Tongue: English
Weight: 62 KB
Volume: 46
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm034098e

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Design and synthesis of N6-substituted-4

Design and synthesis of N6-substituted-4′-thioadenosine-5′-uronamides as potent and selective human A3 adenosine receptor agonists

✍ Won Jun Choi; Hyuk Woo Lee; Hea Ok Kim; Moshe Chinn; Zhan-Guo Gao; Amit Patel; K 📂 Article 📅 2009 🏛 Elsevier Science 🌐 English ⚖ 309 KB

Structure−Activity Relationships of 2-Ch

Structure−Activity Relationships of 2-Chloro-N6-substituted-4‘-thioadenosine-5‘-uronamides as Highly Potent and Selective Agonists at the Human A3 Adenosine Receptor

✍ Jeong, Lak Shin; Lee, Hyuk Woo; Jacobson, Kenneth A.; Kim, Hea Ok; Shin, Dae Hon 📂 Article 📅 2006 🏛 American Chemical Society 🌐 English ⚖ 259 KB

Multidimensional Drug Design: Simultaneo

Multidimensional Drug Design: Simultaneous Analysis of Binding and Relative Efficacy Profiles of N6-substituted-4′-thioadenosines A3 Adenosine Receptor Agonists

✍ Maykel Cruz-Monteagudo; M. Natália D. S. Cordeiro; Marta Teijeira; Maykel P. Gon 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 427 KB

The Synthesis of Highly Potent, Selectiv

The Synthesis of Highly Potent, Selective, and Water-Soluble Agonists at the Human Adenosine A3 Receptor.

✍ Michael DeNino; et al. et al. 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 12 KB 👁 3 views

Synthesis and Biological Evaluation of N

Synthesis and Biological Evaluation of Novel N 6 -[4-(Substituted)sulfonamidophenylcarbamoyl]adenosine-5‘-uronamides as A 3 Adenosine Receptor Agonists

✍ Baraldi, Pier Giovanni; Fruttarolo, Francesca; Tabrizi, Mojgan Aghazadeh; Romagn 📂 Article 📅 2004 🏛 American Chemical Society 🌐 English ⚖ 80 KB

Radiolabeling and efficient synthesis of

Radiolabeling and efficient synthesis of tritiated 2-chloro-N6-(3-iodobenzyl)adenosine-5′-N-methyluron-amide, a potent, selective A3 adenosine receptor agonist

✍ H.O. Kim; C. Hawes; P. Towers; K.A. Jacobson 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 599 KB

We recently reported that 2-substitution of M-benzyladenosine-5'-uronamides greatly enhances selectivity of agonists for rat A, adenosine receptors (J. Med. Chem. 1994, 37, 3614-3621). Specifically, 2-Chloro-M-(3-iodobenzyl)adenosine-5'-Nmethyluronamide (2-CI-IB-MECA), which displayed a K, value of