N-(4-hydroxyphenyl)retinamide (Fenretinide) and nephrectomy alter normal plasma retinol-binding protein metabolism

Secretion of N-(4-hydroxyphenyl) retinam

Secretion of N-(4-hydroxyphenyl) retinamide-retinol-binding protein from liver parenchymal cells: Evidence for reduced affinity of the complex for transthyretin

✍ Kirsten B. Holven; Vasanti Natarajan; Thomas E. Gundersen; Jan Øivind Moskaug; K 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 89 KB

The synthetic retinoid 4-HPR has been shown to markedly lower the plasma concentration of both retinol and RBP in rats and humans. We have studied the effect of 4-HPR on the secretion of retinol-RBP from liver cells in vivo and in vitro. In rats maintained with a normal diet, a vitamin A-deficient d