## Abstract 2‐(4‐Methoxyphenyl)‐__N__‐(4‐methylbenzyl)‐__N__‐(1‐methylpiperidin‐4‐yl)acetamide (AC90179, **4**), a highly potent and selective competitive 5‐HT~2A~ antagonist, was labeled by [^11^C]‐methylation of the corresponding desmethyl analogue **5** with [^11^C]methyl triflate. The precursor
N-[(2′-Cyanobiphenyl-4-yl)methyl]-l-valine methyl ester hydrochloride: an intermediate in the synthesis of valsartan
✍ Scribed by Yathirajan, Hemmige S. ;Nagaraj, Basavegowda ;Gaonkar, Santhosh L. ;Narasegowda, Rajenahally S. ;Nagaraja, Padmarajaiah ;Prabhuswamy, Basappa ;Bolte, Michael
- Publisher
- International Union of Crystallography
- Year
- 2004
- Tongue
- English
- Weight
- 254 KB
- Volume
- 60
- Category
- Article
- ISSN
- 1600-5368
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✦ Synopsis
Experimental
An equimolar mixture of 4 H -bromomethylbiphenyl-2-carbonitrile (1.36 g, 0.005 mol), l-valine methyl ester (0.655 g, 0.005 mol) and
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v
An alternative synthesis of 7-chloro-N-methyl-5-(1H-pyrrol-2-yl)-3H-1,4-benzodiazepin-2-amine, the compound that inhibits gene expression by HIV-1 at the level of transcriptional transactivation by Tat, has been developed. The process is based on ring expansion of 6-chloro-2-chloromethyl-4-(1H-pyrro