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N-[11C]methylpiperidine esters as acetylcholinesterase substrates: an in vivo structure–reactivity study

✍ Scribed by MichaelR. Kilbourn; ThinhB. Nguyen; ScottE. Snyder; Phillip Sherman

Book ID
117688321
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
308 KB
Volume
25
Category
Article
ISSN
0969-8051

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In vivo studies of acetylcholinesterase
In vivo studies of acetylcholinesterase activity using a labeled substrate, N-[11C]methylpiperdin-4-yl propionate ([11C]PMP)
✍ Michael R. Kilbourn; Scott E. Snyder; Phillip S. Sherman; David E. Kuhl 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 958 KB

Two esters, N-["Clmethylpiperidyl acetate ([WIAMP) and N-["C]methylpiperidyl propionate PCIPMP), were synthesized in no-carrier-added forms and evaluated as in vivo substrates for brain acetylcholinesterase (AChE). After peripheral injection in mice, each ester showed rapid penetration into the brai