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(–)-Myrtenyl N,N-Diisopropylcarbamate: Stereochemistry of Lithiation and Electrophilic Substitution Directed by Dynamic Kinetic Diastereoisomer Resolution

✍ Scribed by Thérèse Hémery; Jochen Becker; Roland Fröhlich; Dieter Hoppe


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
417 KB
Volume
2010
Category
Article
ISSN
1434-193X

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## Abstract Proton abstraction of __N__‐__tert__‐butoxycarbonyl‐piperidine (__N__‐Boc‐piperidine) with __s__BuLi and TMEDA provides a racemic organolithium that can be resolved using a chiral ligand. The enantiomeric organolithiums can interconvert so that a dynamic resolution occurs. Two mechanism