Asymmetric Substitutions of 2-Lithiated
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Iain Coldham; Sophie Raimbault; David T. E. Whittaker; Praful T. Chovatia; Danie
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Article
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2010
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John Wiley and Sons
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English
⚖ 343 KB
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## Abstract Proton abstraction of __N__‐__tert__‐butoxycarbonyl‐piperidine (__N__‐Boc‐piperidine) with __s__BuLi and TMEDA provides a racemic organolithium that can be resolved using a chiral ligand. The enantiomeric organolithiums can interconvert so that a dynamic resolution occurs. Two mechanism