Myosin functions inXenopus retinal ganglion cell growth cone motilityin vivo
✍ Scribed by Ruchhoeft, Maureen L. ;Harris, William A.
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 239 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0022-3034
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✦ Synopsis
The role of myosins in Xenopus retiand eventually to freeze, whereas ML-7 caused total nal ganglion cell growth cone motility in the optic collapse and retraction. Concentrations of BDM and tract was studied using two pharmacologic inhibitors with different specificities. 2,3-Butanedione monoxime ML-7 that had no effect when applied independently (BDM) disrupts myosin-actin interactions of all myostopped growth cones when applied simultaneously, sins, and ML-7 specifically inhibits activation of myosuggesting that these inhibitors act synergistically on sin II. Both inhibitors caused growth cones to assume myosin function, thus providing evidence of specifica collapsed morphology and decreased growth cone ity. These results imply that normal growth cone mospeed. Similar effects were observed in vitro. Interesttility in the molecularly and spatially complex enviingly, the effects of the two inhibitors, while similar, ronment of the living brain requires myosin function. were clearly distinguishable, raising the possibility