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Myocardial T2 quantitation in patients with iron overload at 3 Tesla

✍ Scribed by Hua Guo; Wing-Yan Au; Jerry S. Cheung; Daniel Kim; Jens H. Jensen; Pek-Lan Khong; Queenie Chan; Kevin C. Chan; Christina Tosti; Haiying Tang; Truman R. Brown; Wynnie W.M. Lam; Shau-Yin Ha; Gary M. Brittenham; Ed X. Wu

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
584 KB
Volume
30
Category
Article
ISSN
1053-1807

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Purpose

To investigate the feasibility of measuring myocardial T2 at 3 Tesla for assessment of tissue iron in thalassemia major and other iron overloaded patients.

Materials and Methods

A single‐breathhold electrocardiogram‐triggered black‐blood multi‐echo spin‐echo (MESE) sequence with a turbo factor of 2 was implemented at 3 Tesla (T). Myocardial and liver T2 values were measured with three repeated breathholds in 8 normal subjects and 24 patients. Their values, together with the T2* values measured using a breathhold multi‐echo gradient‐echo sequence, were compared with those at 1.5T in the same patients.

Results

At 3T, myocardial T2 was found to be 39.6 ± 7.4 ms in normal subjects. In patients, it ranged from 12.9 to 50.1 ms. T2 and T2* were observed to correlate in heart (ρ = 0.93, ρ < 0.0001) and liver (P = 0.95, P < 0.0001). Myocardial T2 and T2* at 3T were also highly correlated with the 1.5T measurements. Preliminary results indicated that myocardial T2 quantitation was relatively insensitive to B1 variation, and reproducible with 3.2% intra‐exam and 3.8% inter‐exam variations.

Conclusion

Myocardial T2 quantitation is feasible at 3T. Given the substantially decreased T2* and increased B0 inhomogeneity, the rapid myocardial T2 measurement protocol demonstrated here may present a robust alternative to study cardiac iron overload at 3T. J. Magn. Reson. Imaging 2009;30:394–400. © 2009 Wiley‐Liss, Inc.

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Guo H, Au W-Y, Cheung JS, et al. Myocardial T2 quantitation in patients with iron overload at 3 Tesla. J Magn Reson Imaging 2009;30:394–400
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