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Myo-inositol-1-phosphate synthase from streptomyces griseus (Studies on the biosynthesis of cyclitols, XXXVIII1)

✍ Scribed by Fritz Pittner; Irina I. Tovarova; Elena Ya. Kornitskaya; Aleksander S. Khokhlov; Otto Hoffmann-Ostenhof

Publisher: Springer
Year: 1979
Tongue: English
Weight: 271 KB
Volume: 25
Category: Article
ISSN: 0300-8177
DOI: 10.1007/bf00211140

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✦ Synopsis

It could be shown that Streptomyces griseus, the microorganism producing the antibiotic streptomycin and also mutant strains of this species that cannot synthesize streptomycin, possess myo-inositol-1-phosphate synthase (EC 5.5.1.4), the enzyme cyclizing D-glucose 6-phosphate. The enzyme isolated from that organism is extremely instable, its molecular weight is approximately 260,000, and it requires a divalent metal ion for its activity. This is the first instance that an enzyme of this specificity has been found in a prokaryotic organism.

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Preparation of homogeneous crystals of myo-inositol 1-phosphate synthase from rat testicles — further data on the chemical and catalytic properties of the enzyme (studies on the biosynthesis cyclitols XXXIX1)

✍ Fritz Pittner; Otto Hoffmann-Ostenhof 📂 Article 📅 1979 🏛 Springer 🌐 English ⚖ 316 KB

Pre-purified preparations of myoinositol-1-phosphate synthase (E.C. 5.5.1.4) from rat testes can be purified to homogeneity by first crystallizing the enzyme according to JAKOBY and then recrystallizing it at a pH value close to the isoelectric point while slowly increasing the temperature from 0 to