MYH9 and APOL1 are both associated with sickle cell disease nephropathy
โ Scribed by Allison E. Ashley-Koch; Emmanuel C. Okocha; Melanie E. Garrett; Karen Soldano; Laura M. De Castro; Jude C. Jonassaint; Eugene P. Orringer; James R. Eckman; Marilyn J. Telen
- Book ID
- 108677407
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 221 KB
- Volume
- 155
- Category
- Article
- ISSN
- 0007-1048
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In patients with sickle cell disease, anemia is a recognized risk factor for stroke, death, and the development of pulmonary hypertension. We have proposed that hemolytic anemia results in endothelial dysfunction and vascular instability and can ultimately lead to a proliferative vasculopathy leadin
Sickle cell disease (SCD) patients are prone to develop complications that include stroke, acute chest syndrome, and other crises. Some of these complications require chronic transfusion therapy or red cell exchange (RCE), either for therapeutic or prophylactic reasons. Due to a discrepancy of red c