๐”– Bobbio Scriptorium
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Myelomastocytic leukemia versus mast cell leukemia versus systemic mastocytosis associated with acute myeloid leukemia: A diagnostic challenge

โœ Scribed by Angela R. Arredondo; Jason Gotlib; Luke Shier; Bruno Medeiros; Kathleen Wong; Athena Cherry; Christopher Corless; Daniel A. Arber; Peter Valent; Tracy I. George


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
366 KB
Volume
85
Category
Article
ISSN
0361-8609

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โœฆ Synopsis


A physician or group of physicians considers presentation and evolution of a real clinical case, reacting to clinical information and data (boldface type). This is followed by a discussion/commentary.


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Mast cell disease (MCD), a proliferation of mast cells (MC), is occasionally associated with hematologic malignancies. Neoplastic MC have activating c-kit mutations. c-kit is a receptor tyrosine kinase required for the development, proliferation, and survival of MC. Interaction of c-kit with its lig