Myeloma stem cell concepts, heterogeneity and plasticity of multiple myeloma
✍ Scribed by Kotouček, Pavel P.; Orfao, Alberto
- Book ID
- 121850725
- Publisher
- John Wiley and Sons
- Year
- 2014
- Tongue
- English
- Weight
- 48 KB
- Volume
- 166
- Category
- Article
- ISSN
- 0007-1048
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## Abstract To investigate the genetic basis of the great heterogeneity observed in the clinical behavior of multiple myeloma (MM), a combined approach of G‐banding, interphase fluorescence in situ hybridization (FISH), and multicolor FISH (M‐FISH) was employed to analyze 70 samples from 53 patient
High-dose therapy with autologous stem cell transplantation (ASCT) has been extensively used in the past 15 years in multiple myeloma. The IFM 90 trial has shown that autologous bone marrow transplantation (BMT) is superior to conventional chemotherapy in terms of response rate, event free survival,