Myeloid Leukemia: Methods and Protocols
β Harry Iland, Mark Hertzberg, Paula Marlton
π Library
π
2005
π Humana Press
π English
β¦ LIBER β¦
π
Myeloid Leukemia: Methods and Protocols
β Scribed by Harry Iland, Mark Hertzberg, Paula Marlton
- Publisher
- Humana Press
- Year
- 2005
- Tongue
- English
- Leaves
- 319
- Series
- Methods in Molecular Medicine
- Edition
- 1
- Category
- Library
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β¦ Synopsis
A panel of internationally recognized research scientists and clinical investigators brings together a diverse collection of readily reproducible methods for identifying and quantifying a large number of specific genetic abnormalities associated with the broad spectrum of myeloid malignancies. Highlights include techniques for the detection of BCR-ABL mutations and resistance to imatinib mesylate, detection of the FIP1L1-PDGFRA fusion in idiopathic hypereosinophilic syndrome and chronic eosinophilic leukemia, classification of AML by DNA-oligonucleotide microarrays, and detection of the V617F JAK2 mutation in myeloproliferative disorders. In addition to gene rearrangments, other prognostically relevant molecular lesions such as FLT3 mutations and WT-1 overexpression are covered.
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