Myelodysplastic Syndromes

✍ Scribed by H. Joachim Deeg, David T. Bowen, Steven D. Gore, Torsten Haferlach, Michelle M. Le Beau, Charlotte Niemeyer (auth.)

Publisher: Springer-Verlag Berlin Heidelberg
Year: 2013
Tongue: English
Leaves: 245
Series: Hematologic Malignancies
Edition: 2
Category: Library

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✦ Synopsis

The diagnosis of myelodysplastic syndromes (MDS), a heterogeneous group of clonal hematopoietic disorders, is being made with increasing frequency over the past decade owing to increased recognition, improved understanding, and an aging population. This book, completely updated since the first edition, summarizes in a concise and focused way the current knowledge of all aspects of MDS. Clinical presentation, etiology, epidemiology, molecular biology, classification, and staging are all discussed. Clear guidance is provided on diagnosis and differential diagnosis, and treatment strategies are explained in detail, including administration of hematopoietic growth factors, biologically based treatment, hematopoietic stem cell transplantation, and supportive care. Additional chapter is devoted to MDS in children. This practically oriented book will be of value to a broad spectrum of students and practitioners in the field.

✦ Table of Contents

Front Matter....Pages i-viii
Front Matter....Pages 1-1
Clinical Presentation and Differential Diagnosis....Pages 3-8
Epidemiology and Etiology....Pages 9-38
Front Matter....Pages 39-39
Cytogenetic Diagnosis of Myelodysplastic Syndromes....Pages 41-72
MDS Stem Cell Biology....Pages 73-84
The Biology of Myelodysplastic Syndrome Associated with Isolated del(5q)....Pages 85-95
A Personalized Molecular Pathogenesis of MDS....Pages 97-109
Myelodysplastic/Myeloproliferative Neoplasms....Pages 111-126
Classification and Staging of Myelodysplastic Syndromes....Pages 127-139
Immunophenotyping in Myelodysplastic Syndromes....Pages 141-152
Prognostic Models for Patients with Myelodysplastic Syndromes....Pages 153-167
Front Matter....Pages 169-169
Management of Low-Risk MDS....Pages 171-187
Management of High-Risk Myelodysplastic Syndrome....Pages 189-210
Hematopoietic Cell Transplantation (HCT)....Pages 211-228
Front Matter....Pages 229-229
Myelodysplastic Syndrome in Children....Pages 231-240
Back Matter....Pages 241-245

✦ Subjects

Hematology; Internal Medicine; Oncology; Pathology; Transplant Surgery

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