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Myelin/oligodendrocyte-specific protein: A novel surface membrane protein that associates with microtubules

✍ Scribed by C. A. Dyer; W. F. Hickey; E. E. Geisert Jr.

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 734 KB
Volume: 28
Category: Article
ISSN: 0360-4012
DOI: 10.1002/jnr.490280418

No coin nor oath required. For personal study only.

✦ Synopsis

Only a few proteins are known to be exclusively expressed in central nervous system (CNS) myelin. A novel surface membrane protein expressed only in CNS myelin and oligodendrocytes of higher vertebrates has been identified by a monoclonal antibody. This CNS myelin/oligodendrocyte-specific protein, MOSP, has a molecular weight of 48 kDa and a PI of approximately 6.7. In the presence of the monoclonal antibody, MOSP remains on the surface of cultured oligodendrocytes but becomes associated with cytoplasmic microtubules. Our results suggest that MOSP plays an important role in membranekytoskeleton interactions during the formation and maintenance of CNS myelin. MOSP also may play a critical role in the pathogenesis of diseases of CNS myelin.

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