Myelination by the transplanted oligodendrocytes in the shiverer mutant mouse brain
β Scribed by Kohsaka, Shinichi; Takayama, Hideichi; Shinozaki, Tomofumi; Inoue, Yoshiro; Yoshida, Kazunari; Inoue, Hiroshi; Mikoshiba, Katsuhiko; Otani, Mitsuhiro; Toya, Shigeo; Tsukada, Yasuzo
- Book ID
- 123332898
- Publisher
- Elsevier Science
- Year
- 1986
- Weight
- 70 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0921-8696
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Myelin basic protein (MBP)-specific protein-arginine N-methyltransferase (protein methylase I) activity in homozygous shiverer (shilshi) mutant mouse brain is significantly higher than in the normal littermate brain at the onset of myelination. While the enzyme activity (expressed as pmol of S-adeno
Transferrin, the iron mobilization protein, and its mRNA are normally present in oligodendrocytes. Previous reports using myelin mutants have shown both a decrease in transferrin protein and mRNA when the oligodendrocyte population is compromised. In this study the shiverer mouse mutant in which the